OAS1 polyclonal antibody
产品名称： OAS1 polyclonal antibody
英文名称： OAS1 polyclonal antibody
产品编号： PAB4810
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of OAS1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human OAS1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.
Wang H, Ghosh A, Baigude H, Yang CS, Qiu L, Xia X, Zhou H, Rana TM, Xu Z.J Biol Chem. 2008 Jun 6;283(23):15845-52. Epub 2008 Mar 26.
- 2.
- A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ.J Virol. 2007 Jun;81(11):5561-72. Epub 2007 Mar 7.
- 3.
- IFI16 in human prostate cancer.
Alimirah F, Chen J, Davis FJ, Choubey D.Mol Cancer Res. 2007 Mar;5(3):251-9. Epub 2007 Mar 5.
- Applications
- Western Blot (Tissue lysate)
- The OAS1 polyclonal antibody (Cat # PAB4810) is used in Western blot to detect OAS1 in mouse liver lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 polyclonal antibody (Cat # PAB4810) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4938
- Protein Accession#:
- NP_002525;P00973
- Gene Name:
- OAS1
- Gene Alias:
- IFI-4,OIAS,OIASI
- Gene Description:
- 2',5'-oligoadenylate synthetase 1, 40/46kDa
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
- Other Designations:
- (2'-5') oligoadenylate synthetase 1,2',5'-oligo A synthetase 1,2',5'-oligoadenylate synthetase 1,2',5'-oligoadenylate synthetase 1 (40-46 kD),2'-5' oligoadenylate synthetase 1 p48 isoform,2'-5' oligoadenylate synthetase 1 p52 isoform,2'-5'-oligoisoadenyla
- Related Disease