FITC标记的肿瘤坏死因子受体相关蛋白4抗体
产品名称： FITC标记的肿瘤坏死因子受体相关蛋白4抗体
英文名称： Anti-TRAF4/FITC
产品编号： HZ-8545R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TRAF4/FITC Conjugated antibody
FITC标记的肿瘤坏死因子受体相关蛋白4抗体
| 英文名称 | Anti-TRAF4/FITC |
| 中文名称 | FITC标记的肿瘤坏死因子受体相关蛋白4抗体 |
| 别 名 | CART 1; CART1; TRAF 4; TRAF-4; TRAF4_HUMAN; cysteine rich domain associated with ring and TRAF domain; Cysteine rich domain associated with RING and Traf domains protein 1; Malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; RING finger protein 83; RNF 83; RNF83; TNF receptor associated factor 4; TRAF 4; tumor necrosis receptor-associated factor 4A. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRAF4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]. Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Subunit: Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Tissue Specificity: Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. Post-translational modifications: Polyubiquitinated, leading to its proteasomal degradation. Similarity: Contains 1 MATH domain. Contains 1 RING-type zinc finger. Contains 3 TRAF-type zinc fingers. Database links: Entrez Gene: 9618 Human Entrez Gene: 22032 Mouse Omim: 602464 Human SwissProt: Q9BUZ4 Human SwissProt: Q61382 Mouse Unigene: 8375 Human Unigene: 390418 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码TNF受体相关因子（TRAF）家族的成员。TRAF蛋白与TNF受体超家族成员相关，并介导信号转导。该编码蛋白与神经营养素受体p75(NTR/NTSR1)相互作用，负性调节NTR诱导的细胞死亡和NF-κB活化。已发现该蛋白与p47phox结合，p47phox是包含在被称为NAD(P)H氧化酶的多蛋白复合物中的细胞质调节因子。因此，这种蛋白被认为参与MAPK8/JNK的氧化激活。已观察到另一种剪接的转录体变体，但已确定只有一个的全长性质。[ RefSeq，JUL 2008 ]提供。