Western blot analysis of GluN1-NR1 in rat brain membrane tissues, using a 1:1000 dilution of SMC-410.

The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling
synaptic plasticity and memory function (1). The NMDA receptor forms a heterotetramer between two NR1 and
two NR2 subunits (the subunits are also called glutamatebinding NMDA receptor subunits or GluN for short); two
obligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunits
have an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions and
functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2
subunits.

1. Li F., and Tsien J.Z. (2009) Clinical Implications of Basic Research: Memory and the NMDA receptors. New
England J. Medicine. 361: 302-303.
2. Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547.
3. Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282(35): 25299- 25307.