Thapsigargin (CAS: 67526-95-8)
产品名称： Thapsigargin (CAS: 67526-95-8)
英文名称： Thapsigargin
产品编号： SIH-399-5MG
产品价格： 0
产品产地： 加拿大
品牌商标： StressMarq
更新时间： null
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Thapsigargin is a cell-permeable inhibitor of the sarco-endoplasmatic reticulum Ca2+-ATPase (SERCA). This inhibition causes the release of intracellular Ca2+ stores. Thapsigargin also inhibits autophagy. This is due to the induction of and an ER stress response, which causes downstream effects that include an accumulation of autophagosomes in the cytosol. These intermediate structures never mature into amphisomes and autolysosomes, and the autophagy process cannot be completed.